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THYROXINE
Descriptors Found:
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DeCS
Descriptor
English
:
Thyroxine
Descriptor
Spanish
:
Tiroxina
Descriptor
Portuguese
:
Tiroxina
Synonyms
English
:
Levothyroxine
L-Thyroxine
T4 Thyroid Hormone
Tree Number:
D06.472.931.812
D12.125.072.050.767
Definition
English
:
The major hormone derived from the
thyroid gland
.
Thyroxine
is synthesized via the iodination of tyrosines (
MONOIODOTYROSINE
) and the coupling of iodotyrosines (
DIIODOTYROSINE
) in the
THYROGLOBULIN
.
Thyroxine
is released from
thyroglobulin
by
proteolysis
and secreted into the blood.
Thyroxine
is peripherally deiodinated to form
TRIIODOTHYRONINE
which exerts a broad spectrum of stimulatory effects on cell
metabolism.
Indexing Annotation
English
:
/blood
: consider also
HYPERTHYROXINEMIA
See Related
English
:
Hyperthyroxinemia
Receptors, Thyroid Hormone
History Note
English
:
1965; use THYROXIN 1963-1964; for LEVOTHYROXINE use LEVOTHYROXINE 1991-2001, use THYROXINE 1966-1990
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AA
analogs & derivatives
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DU
diagnostic use
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UR
urine
Record Number:
14360
Unique Identifier:
D013974
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
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