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ONCOGENES
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DeCS
Descriptor
English
:
Oncogenes
Descriptor
Spanish
:
Oncogenes
Descriptor
Portuguese
:
Oncogenes
Synonyms
English
:
Transforming Genes
Tree Number:
G05.360.340.024.340.375.500
Definition
English
:
Genes whose gain-of-function alterations lead to NEOPLASTIC CELL TRANSFORMATION. They include, for example, genes for activators or stimulators of
CELL PROLIFERATION
such as
growth
factors,
growth
factor receptors,
protein kinases
, signal
transducers
, nuclear
phosphoproteins
, and
transcription factors
. A prefix of "v-" before oncogene symbols indicates
oncogenes
captured and transmitted by RETROVIRUSES; the prefix "c-" before the gene symbol of an oncogene indicates it is the cellular homolog (
PROTO-ONCOGENES
) of a v-oncogene.
Indexing Annotation
English
:
"oncogene" used by author may refer to
ONCOGENES
or
PROTO-ONCOGENES
; do not confuse with ONCOGENS see
CARCINOGENS
; Manual 24.4.4.3; do not confuse with GENES, NEOPLASM
History Note
English
:
83
Allowable Qualifiers
English
:
DE
drug effects
ES
ethics
GE
genetics
IM
immunology
PH
physiology
RE
radiation effects
Record Number:
10040
Unique Identifier:
D009857
Occurrence in VHL
:
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