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BETA-N-ACETYLHEXOSAMINIDASES
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DeCS
Descriptor
English
:
beta-N-Acetylhexosaminidases
Descriptor
Spanish
:
beta-N-Acetilhexosaminidasas
Descriptor
Portuguese
:
beta-N-Acetil-Hexosaminidases
Synonyms
English
:
beta-N-Acetylhexosaminidase
Tree Number:
D08.811.277.450.483.180
Definition
English
:
A hexosaminidase specific for non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides. It acts on
GLUCOSIDES
;
GALACTOSIDES
; and several
OLIGOSACCHARIDES
. Two specific mammalian
isoenzymes
of beta-N-acetylhexoaminidase are referred to as
HEXOSAMINIDASE A
and
HEXOSAMINIDASE B
. Deficiency of the type A isoenzyme causes
TAY-SACHS DISEASE
, while deficiency of both A and B
isozymes
causes
SANDHOFF DISEASE
. The enzyme has also been used as a tumor marker to distinguish between malignant and benign
disease.
Indexing Annotation
English
:
do not confuse with
ACETYLGLUCOSAMINIDASE
; /defic: consider also TAY SACHS
DISEASE
and
SANDHOFF DISEASE
See Related
English
:
Sandhoff Disease
Tay-Sachs Disease
History Note
English
:
2008(1988)
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DU
diagnostic use
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
19087
Unique Identifier:
D001619
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS