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SEPARASE
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DeCS
Descriptor
English
:
Separase
Descriptor
Spanish
:
Separasa
Descriptor
Portuguese
:
Separase
Tree Number:
D08.811.277.656.262.500.792
D08.811.277.656.300.200.792
D12.776.167.552
Definition
English
:
Separase
is a caspase-like
cysteine
protease, which plays a central role in triggering
ANAPHASE
by cleaving the SCC1/RAD21 subunit of the cohesin complex. Cohesin holds the sister
CHROMATIDS
together during
METAPHASE
and its cleavage results in
chromosome segregation.
History Note
English
:
2014
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DU
diagnostic use
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
55268
Unique Identifier:
D064247
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS