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INTERFERON-ALPHA
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DeCS
Descriptor
English
:
Interferon-alpha
Descriptor
Spanish
:
Interferón-alfa
Descriptor
Portuguese
:
Interferon-alfa
Synonyms
English
:
Interferon Alfa
alpha-Interferon
Interferon, Leukocyte
Interferon, Lymphoblast
Tree Number:
D12.644.276.374.440.890.250
D12.644.276.718.500.250
D12.776.467.374.440.890.250
D12.776.467.718.500.250
D23.529.374.440.890.250
D23.529.718.500.250
Definition
English
:
One of the type I
interferons
produced by peripheral blood
leukocytes
or lymphoblastoid cells. In addition to antiviral activity, it activates NATURAL KILLER CELLS and
B-LYMPHOCYTES
, and down-regulates VASCULAR ENDOTHELIAL
GROWTH
FACTOR expression through PI-3 KINASE and MAPK KINASES signaling pathways.
Pharmacological Action:
Antiviral Agents
Immunologic Factors
History Note
English
:
1992; for INTERFERON, LYMPHOBLAST and INTERFERON, LEUKOCYTE use INTERFERON TYPE I 1989-1991
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DU
diagnostic use
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
30033
Unique Identifier:
D016898
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS