Pesquisa sobre:
PRESENILIN-1
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DeCS
Descritor
Inglês
:
Presenilin-1
Descritor
Espanhol
:
Presenilina-1
Descritor
Português
:
Presenilina-1
Categoria:
D12.776.543.696.500
Definição
Inglês
:
Integral membrane protein of Golgi and
endoplasmic reticulum
. Its homodimer is an essential component of the gamma-secretase complex that catalyzes the cleavage of
membrane proteins
such as
NOTCH RECEPTORS
and
AMYLOID BETA-PEPTIDES
precursors. PSEN1 mutations cause early-onset
ALZHEIMER DISEASE
type 3 that may occur as early as 30 years of age in
humans.
Nota Histórica
Inglês
:
2007
Qualificadores Permitidos
Inglês
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DU
diagnostic use
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Número do Registro:
52334
Identificador Único:
D053764
Ocorrência na BVS
:
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