Search on: OSTEOCALCIN 
Descriptors Found: 1
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Descriptor English:   Osteocalcin 
Descriptor Spanish:   Osteocalcina 
Descriptor Portuguese:   Osteocalcina 
Synonyms English:   Bone Gla Protein
Calcium-Binding Protein, Vitamin K-Dependent
Vitamin K-Dependent Bone Protein
Gla Protein, Bone  
Tree Number:   D12.776.157.125.700
Definition English:   Vitamin K-dependent calcium-binding protein synthesized by OSTEOBLASTS and found primarily in BONES. Serum osteocalcin measurements provide a noninvasive specific marker of bone metabolism. The protein contains three residues of the amino acid gamma-carboxyglutamic acid (Gla), which, in the presence of CALCIUM, promotes binding to HYDROXYAPATITE and subsequent accumulation in BONE MATRIX. 
History Note English:   90; GLA-PROTEIN was see OSTEOCACLIN 1990-96 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification CT contraindications
DF deficiency DU diagnostic use
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
SE secretion ST standards
SD supply & distribution TU therapeutic use
TO toxicity UL ultrastructure
UR urine  
Record Number:   24820 
Unique Identifier:   D015675 

Occurrence in VHL:
 

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