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6-MERCAPTOPURINE
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DeCS
Descriptor
English
:
6-Mercaptopurine
Descriptor
Spanish
:
6-Mercaptopurina
Descriptor
Portuguese
:
6-Mercaptopurina
Tree Number:
D02.886.489.534
D03.438.759.534
Definition
English
:
An antimetabolite antineoplastic agent with immunosuppressant properties. It interferes with nucleic acid synthesis by inhibiting purine
metabolism
and is used, usually in combination with other drugs, in the treatment of or in remission
maintenance
programs
for
leukemia.
Pharmacological Action:
Antimetabolites
Antimetabolites, Antineoplastic
Immunosuppressive Agents
Nucleic Acid Synthesis Inhibitors
History Note
English
:
85; was MERCAPTOPURINE 1963-84; ARABINOSYL-6-MERCAPTOPURINE was heading 1975-91 (see under 6-MERCAPTOPURINE 1975-90)
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AA
analogs & derivatives
AN
analysis
AI
antagonists & inhibitors
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DU
diagnostic use
EC
economics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UR
urine
Record Number:
8800
Unique Identifier:
D015122
Occurrence in VHL
:
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DeCS
CID-10
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