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EPOPROSTENOL
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DeCS
Descriptor
English
:
Epoprostenol
Descriptor
Spanish
:
Epoprostenol
Descriptor
Portuguese
:
Epoprostenol
Synonyms
English
:
Prostacyclin
Prostaglandin I2
PGI2
PGX
Tree Number:
D10.251.355.255.100.637.550.500
D10.251.355.255.550.550.500
D23.469.050.175.725.895.500
Definition
English
:
A prostaglandin that is a powerful vasodilator and inhibits
platelet aggregation
. It is biosynthesized enzymatically from
PROSTAGLANDIN ENDOPEROXIDES
in human vascular tissue. The
sodium
salt has been also used to treat primary
pulmonary hypertension
(
HYPERTENSION
, PULMONARY).
Indexing Annotation
English
:
/chem syn permitted: do not convert to
PROSTAGLANDINS
, SYNTHETIC; DF: PGX
Pharmacological Action:
Antihypertensive Agents
Platelet Aggregation Inhibitors
History Note
English
:
91(78); was PROSTAGLANDINS X 1978-90 (see under PROSTAGLANDINS 1978-83); PROSTACYCLIN was PROSTACYCLINS 1978-93; PROSTAGLANDIN I2 was PROSTAGLANDINS I2 1982-93; PROSTAGLANDIN X was PROSTAGLANDINS X 1991-93
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AA
analogs & derivatives
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DU
diagnostic use
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UR
urine
Record Number:
29280
Unique Identifier:
D011464
Occurrence in VHL
:
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DeCS
CID-10
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