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PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 22
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DeCS
Descriptor
English
:
Protein Tyrosine Phosphatase, Non-Receptor Type 22
Descriptor
Spanish
:
Proteína Tirosina Fosfatasa no Receptora Tipo 22
Descriptor
Portuguese
:
Proteína Tirosina Fosfatase não Receptora Tipo 22
Tree Number:
D08.811.277.352.650.775.300.930
D12.644.360.585.930
D12.776.476.564.930
Definition
English
:
A subtype of non-receptor
protein tyrosine phosphatases
that is characterized by the presence of an N-terminal
catalytic domain
and a C-terminal PROLINE-rich domain. The phosphatase subtype is predominantly expressed in
LYMPHOCYTES
and plays a key role in the inhibition of downstream T-LYMPHOCYTE activation. Polymorphisms in the gene that encodes this phosphatase subtype are associated with a variety of
AUTOIMMUNE DISEASES.
History Note
English
:
2008(1999)
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DU
diagnostic use
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
52703
Unique Identifier:
D054596
Occurrence in VHL
:
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