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MEVINOLIN
Descriptors Found:
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DeCS
Descriptor
English
:
Lovastatin
Descriptor
Spanish
:
Lovastatina
Descriptor
Portuguese
:
Lovastatina
Synonyms
English
:
Lovastatin, 1 alpha-Isomer
Mevinolin
Tree Number:
D02.455.426.559.847.638.400
D04.615.638.400
Definition
English
:
A fungal metabolite isolated from cultures of
Aspergillus
terreus. The compound is a potent anticholesteremic agent. It inhibits 3-hydroxy-3-methylglutaryl
coenzyme A
reductase (
HYDROXYMETHYLGLUTARYL COA REDUCTASES
), which is the rate-limiting enzyme in
cholesterol
biosynthesis. It also stimulates the production of low-density
lipoprotein receptors
in the liver.
Pharmacological Action:
Anticholesteremic Agents
Hydroxymethylglutaryl-CoA Reductase Inhibitors
History Note
English
:
88; for MONACOLIN K use LOVASTATIN (NM) 1980-98
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AA
analogs & derivatives
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DU
diagnostic use
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UR
urine
Record Number:
22932
Unique Identifier:
D008148
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS