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MAP-KINASE-ACTIVATED KINASE 1
Descriptors Found:
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DeCS
Descriptor
English
:
Ribosomal Protein S6 Kinases, 90-kDa
Descriptor
Spanish
:
Proteínas Quinasas S6 Ribosómicas 90-kDa
Descriptor
Portuguese
:
Proteínas Quinases S6 Ribossômicas 90-kDa
Synonyms
English
:
MAP-Kinase-Activated Kinase 1
MAP-Kinase-Activated Protein Kinase 1
Tree Number:
D08.811.913.696.620.682.700.862.500
D12.644.360.600.500
D12.776.476.600.500
Definition
English
:
A
family
of
ribosomal protein S6 kinases
that are structurally distinguished from
RIBOSOMAL PROTEIN S6 KINASES
, 70-KDA by their apparent molecular size and the fact they contain two functional kinase domains. Although considered
RIBOSOMAL PROTEIN S6 KINASES
, members of this
family
are activated via the
MAP KINASE SIGNALING SYSTEM
and have been shown to act on a diverse array of
substrates
that are involved in cellular regulation such as
RIBOSOMAL PROTEIN S6
and CAMP RESPONSE ELEMENT-BINDING PROTEIN.
History Note
English
:
2005(2002); for PP90(RSK) & PP90(RSK) use RIBOSOMAL PROTEIN S6 KINASES 1998-2002
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DU
diagnostic use
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
37342
Unique Identifier:
D038744
Occurrence in VHL
:
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CID-10
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