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EGF RECEPTOR
Descriptors Found:
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DeCS
Descriptor
English
:
Receptor, Epidermal Growth Factor
Descriptor
Spanish
:
Receptor del Factor de Crecimiento Epidérmico
Descriptor
Portuguese
:
Receptor do Fator de Crescimento Epidérmico
Synonyms
English
:
c-erbB-1 Protein
EGF Receptor
Epidermal Growth Factor Receptor
Receptor, Transforming-Growth Factor alpha
Urogastrone Receptor
Receptor, TGF-alpha
Receptor, Urogastrone
Transforming Growth Factor alpha Receptor
TGF-alpha Receptor
erbB-1 Proto-Oncogene Protein
Epidermal Growth Factor Receptor Protein-Tyrosine Kinase
Receptor, EGF
Tree Number:
D08.811.913.696.620.682.725.400.009.300
D12.776.543.750.060.009.300
D12.776.543.750.750.360.300
D12.776.543.750.750.400.074.300
Definition
English
:
A cell surface receptor involved in regulation of cell
growth
and differentiation. It is specific for
EPIDERMAL GROWTH FACTOR
and EGF-related
peptides
including
TRANSFORMING GROWTH FACTOR ALPHA
;
AMPHIREGULIN
; and
HEPARIN-BINDING EGF-LIKE GROWTH FACTOR
. The binding of ligand to the receptor causes activation of its intrinsic
tyrosine
kinase activity and rapid internalization of the receptor-ligand complex into the cell.
See Related
English
:
Genes, erbB-1
History Note
English
:
2000(1987); for EPIDERMAL GROWTH FACTOR RECEPTOR PROTEIN-TYROSINE KINASE use RECEPTOR, EPIDERMAL GROWTH FACTOR 1994-1999
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DU
diagnostic use
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
24479
Unique Identifier:
D011958
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS