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COMPLEMENTARITY DETERMINING REGIONS
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DeCS
Descriptor
English
:
Complementarity Determining Regions
Descriptor
Spanish
:
Regiones Determinantes de Complementariedad
Descriptor
Portuguese
:
Regiões Determinantes de Complementaridade
Tree Number:
D12.644.541.500.650.500.180
D12.776.124.486.485.680.650.500.180
D12.776.124.486.485.797.180
D12.776.124.790.651.680.650.500.180
D12.776.124.790.651.797.180
D12.776.377.715.548.680.650.500.180
D12.776.377.715.548.797.180
D12.776.543.750.705.816.824.300
G02.111.570.060.425.160
Definition
English
:
Three regions (CDR1; CDR2 and CDR3) of
amino acid sequence
in the
IMMUNOGLOBULIN VARIABLE REGION
that are highly divergent. Together the CDRs from the light and heavy immunoglobulin chains form a surface that is complementary to the antigen. These regions are also present in other members of the immunoglobulin superfamily, for example, T-cell receptors (RECEPTORS, ANTIGEN, T-CELL).
See Related
English
:
Receptors, Antigen, T-Cell
History Note
English
:
2001; for COMPLEMENTARITY DETERMINING REGION and HYPERVARIABLE REGION use IMMUNOGLOBULIN VARIABLE REGION 1988-2000
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AN
analysis
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CH
chemistry
CL
classification
CT
contraindications
DU
diagnostic use
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
35339
Unique Identifier:
D022801
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS